The Athletics programme at London 2012 will climax with the T12, T46 and T54 women's and men's events, with Great Britain's David Weir likely to draw plenty of attention in the latter race.
Weir will start as favourite, a tag he is more than accustomed to as a six-time winner of the London Marathon.
The looped Paralympic course follows a different route, though, featuring one 2.2-mile and four eight-mile laps, taking in sights such as St Paul's Cathedral, Buckingham Palace and the Houses of Parliament.
Weir is unbeaten at this year's Games, winning all three wheelchair races in which he has competed to claim triple gold in the 5000m, 1500m and 800m.
The 33-year-old said: 'The course is very twisty. It's not going to be banging out top speeds for a long while so hopefully I can get the endurance and get through it. We'll see.'
Weir lines up alongside his long-time rival, Switzerland's Marcel Hug.
The world record holder for the 800m, 1500m and 5000m - T54 has been comprehensively overshadowed so far, watching Weir take gold in the three events.
He said: 'I have to try to [beat Weir]. He's flying. He's very strong, but I still believe he is beatable.
'The key was the first race, the 5000m he won, for his confidence.'