The 25-year-old reigning champion, who trains with USA sprint star Tyson Gay in Florida over the winter, has run even quicker in non-disabled competition - and he insisted he is not finished yet.
He said: 'I know I'm in good shape. I've run 10.20 this year and I was hoping to come out in the heat, get out of the blocks and just chill down the end.
'If I don't come out and run quicker tomorrow I'd be extremely disappointed.'
There was home glory for Britain's Hannah Cockroft, who was roared on to victory in the the women's 100m - T34 by an 80,000 crowd.
Russia's Roman Kapranov won the men's 200m - T37 with China's Liu Ping claiming the women's 200m - T35 title.
Serbia's Zeljko Dimitrijevic set a new F31/32/51 world record of 26.88m to win gold in the Club Throw.
In the women’s Discus - F35/36, Wu Qing of China was awarded the gold medal following a review of results, with Mariia Pomazan of Ukraine taking silver and Katherine Proudfoot of Australia the bronze.
At the Aquatics Centre, USA athlete Jessica Long increased her Paralympic Games medal tally to 11 as she won gold in the 400m Freestyle - S8 in a new world record time of 4:42.28.
Long has dominated the event since the Athens 2004 Paralympics and today's success followed the gold she won yesterday in the 100m Butterfly.
In the Velodrome, Australia's Felicity Johnson and Stephanie Morton opened a dramatic day's action by winning the women's Individual B 1km Time Trial in a Paralympic record of 1:08.919.
The C4-5 1km Time Trial was won by Alfonso Cabello in a C5 world record of 1:05.947 after defending champion Jody Cundy had stopped yards into his ride.
The Briton believed the start gate had failed to open sufficiently but officials deemed rider error was to blame and Cundy was denied a restart.
China's Liang Guihia won the men's Individual C2 Pursuit, clocking a world record of 3:45.243. Britain's Mark Colbourne won the men's C1 event.
On the Shooting range, Olivera Nakovska-Bikova became FYR Macedonia's first-ever Paralympic Games champion with victory in the P2-10m Air Pistol-SH1.
China's Dong Chao won gold in the men's R1-10m Air Rifle Standing-SH1,beating veteran Paralympian Jonas Jakobsson into silver medal position.
Sherif Othman defended his Powerlifting title with his first lift of 197kg. Nigeria's Ivory Nwokorie won the women's -44kg class and China's Feng Qi was victorious in -52kg category.
Ukraine moved top of the Judo standings after Dmytro Solovey and Olexandr Kosinov both won gold medals.
In the women's divisions, Azerbaijan's Afag Sultanova (-57kg) and Cuba's Dalidaivis Rodriguez Clark (-63kg) both took gold.
Chinese crews set world best times in the AS men's Single Sculls and in the Mixed Double Sculls on a record-breaking opening day of the Rowing regatta.
Huang Cheng, who only began competing internationally this year, took advantage of the strong tail-wind at Eton Dorney to take nearly five seconds out of Tom Aggar's previous world best time.
Germany's LTA Mixed Coxed Four - Anke Molkenthin, Astrid Hengsbach, Tino Kolitscher, Kai Kruse and cox Katrin Splitt - took over six seconds out of the world's best time in winning their heat.
France's Perle Bouge and Stephane Tardieu broke the world TA Mixed Double Scull record in winning their heat - only for China's Lou Xiaoxian and Fei Tianming to lower it again in the very next race.
In the Equestrian, Great Britain took a vice-like grip on the Team title after three more outstanding performances at Greenwich Park.
After Lee Pearson topped the Grade Ib class yesterday, Sophie Wells (IV) and Sophie Christiansen (Ia) followed suit today with brilliant displays, and Deb Criddle was second behind defending individual champion Hannelore Brennerin Grade III.
Germany defeated the USA, the reigning Paralympic women's Wheelchair Basketball champions, 54-48 in a rematch of the 2008 final to make a successful start to their campaign.
Czech archer Lenka Kuncova beat her friend and room-mate Miroslava Cerna in the last 16 of the W1/W2 women's Individual Recurve.
China's Goalball teams enjoyed a successful day, with their men defeating Republic of Korea 11-4 in the preliminary round Group B and the women beating Brazil 8-0 in Group C.
Ukraine beat hosts Great Britain 3-0 in the Sitting Volleyball action, while there were also group wins for Netherlands, China, Brazil and Germany.
In the 5-a-side Football, double Paralympic Games champions Brazil opened their campaign with a 0-0 draw against European champions France.