The two poster-boys of this Games - one the face of the Host Nation and the other the biggest icon in Paralympic sport - claimed two of the last gold medals available after 10 thrilling days of action on the track, in the field and on the road.
Pistorius may not have won as many gold medals at London 2012 as he did in Beijing in 2008, but he remains one of the biggest draws in the sport and it was appropriate that he brought the curtain down on the action at the Olympic Stadium with victory in the men's 400m - T44 in a Paralympic record 46.68.
After beating USA duo Blake Leeper and David Prince, the South African said: 'I'm so proud. The summer's been a dream come true. I couldn't have hoped for anything better.'
That sense of achievement was shared by Weir, who followed up his success on the track by claiming gold in the Marathon - T54 on the streets of London.
It completed a remarkable golden quadruple for the Brit, who added the Marathon title to his sensational victories in the 800m, 1500m and the 5000m.
But the Paralympic Athletics programme was far from a two-man show.
China continued their dominance of the sport, claiming a total of 33 gold medals to finish top of the overall medal table.
Two of those were won by Huang Lisha, who followed up success in the women's 100m - T53 with the 200m title. She also took silver in the 800m and bronze in the 400m.
Compatriot Zhou Hongzhuan also claimed four T53 medals on the track, while Wang Zhiming won a golden treble in the men's F40 Shot Put, Discus and Javelin competitions.
Fellow powerhouse the USA were once again a force. Tatyana McFadden's haul of three T54 golds and one bronze made her one of the stars of the Games, while Raymond Martin took four golds in the 100m, 200m, 400m and 800m - T52.
There were other notable successes too - such as for Ireland, for whom Jason Smyth claimed a remarkable sprint double to confirm his place as the fastest Paralympian in the world by winning the 100m and 200m - T13 and team-mate Michael McKillop achieved his own double in the 800m and 1500m - T37.
Lord Seb Coe and his team at LOCOG have done the most amazing Olympic Games and Paralympic Games.Oscar Pistorius
Brazil's Alan Fonteles Cardoso Oliveira announced his arrival as the new sprint force in the 200m - T44, beating Pistorius, before Algeria's Abdellatif Baka timed his finish to perfection to snatch gold in the 800m - T13.
Great Britain's Games was highlighted by a succession of headline-grabbing performances, as Jonnie Peacock won the 100m -T44, Richard Whitehead claimed 200m - T42 glory and Hannah Cockroft did likewise in the 100m and 200m - T34.
There were real human stories too, such as Houssein Omar Hassan of Djibouti - his country's only competitor at the Games - who was cheered home by one of the loudest ovations at the Olympic Stadium as he finished almost seven minutes adrift in his 1500m - T46 heat.
Or Brazil's Yohansson Nascimento, who stubbornly refused to give up in the 100m - T46 despite pulling up injured.
The 24-year-old, a gold medal contender, saw his dreams ended early in the race by an apparent hamstring injury but, fighting back tears and to huge roars from the crowd, Nascimento hauled himself to his feet and limped agonisingly slowly across the line.
It summed up a Games that was just as much about the Paralympic spirit as it was gold, silver and bronze.
As he capped a remarkable final night at the Olympic Stadium, Pistorius perhaps summed it up best.
He reflected: 'Lord Seb Coe and his team at LOCOG have done the most amazing Olympic Games and Paralympic Games.
'These have been some of the biggest highlights of my life.'