Former Formula One driver Alessandro Zanardi will be on familiar territory as the Cycling Road events get under way at Brands Hatch.
The 45-year-old built his own bike from scratch and is set to represent Italy in the men's Individual H 4 Time Trial tomorrow afternoon, when he hopes his knowledge of the track will give him the edge over his rivals and lead him to gold.
Over at the Olympic Stadium, USA athlete Tatyana McFadden is displaying the potential to become one of the stars of the London 2012 Games.
After winning gold in the women's 400m - T54 on Monday evening, she returned to the track the following day to qualify fastest for the final of the women's 800m - T54, a race which will take place on Wednesday night.
'It is a really tough field with competitors like (Edith) Wolf, but I hope I can win,' she said. 'Whatever happens I will give 100 per cent.'
McFadden is among the favourites to land gold in the final and has a further three events to compete in before the Games are over.
In the field events, reigning Paralympic Long Jump - F37/38 champion Mohamed Farhat Chida of Tunisia will face a battle to hold on to his title when he comes up against South Africa's Dyan Buis, whose season's best is more than half a metre further than his rival.
Buis, 21, has already had one medal around his neck having taken silver in the men's 100m -T38 on Saturday night.
Twelve-time Paralympic gold medallist Natalie du Toit returns to the pool in the women's 50m Freestyle - S9 as she tries to win her third title of the Games.
There are also medals on offer in Archery, Powerlifting, Shooting, Wheelchair Fencing and Wheelchair Tennis.