South Africa's Athletics competitor Fanie van der Merwe won gold in the T37 100 and 200m at the Beijing 2008 Games, and he will be hoping to defend the latter title during the evening session.
He finished with silver medals in both events at last year's IPC World Championships, but has since set T37 world records of 11.52 and 23.10.
David Weir and Shelly Woods will also be action in the opening rounds of the men's and women's T54 5000m.
At the Aquatics Centre, South African Natalie du Toit will be going for glory in the women's 100m Backstroke - S9, while brothers Sam and Ollie Hynd take on each other and the rest of the world in the 400m Freestyle - S8.
The Games' most successful male athlete, Swedish shooter Jonas Jakobsson, is aiming to add to his record 28 medals when he begins his ninth Paralympic campaign in the men's R1-10m Air Rifle Standing-SH1 event.
Egypt's world and Paralympic Powerlifting champion Sherif Othman will be in action in the men's -56kg class.
Medals will also be up for grabs in Track Cycling and Judo.