Fresh from an enthralling end to the programme at the Velodrome, attention will switch to Brands Hatch on Day 7, with Czech Jezek one of those expected to challenge for honours.
The C4 racer is targeting a place in the history books, as he aims to add an 11th medal to a haul that stretches all the way back to Sydney 2000.
Jezek has already stepped onto the podium at these Games, taking silver on the track in the men's Individual C4 Pursuit, and he now has the chance to overtake Australia’s Christopher Scott as the most successful Paralympic cyclist of all time.
The opening day of Road Cycling action sees the Time Trials, with a total of 18 medals up for grabs - 10 for men, seven for women and one mixed (T1-2) being decided across all classes.
Colin Lynch of Ireland is world champion in the C2 class and has had a strong results through the 2012 season while other medal hopefuls include Oscar Sanchez of the USA, Jon-Allan Butterworth of Great Britain and Sarah Storey, who will look to shine for the Host Nation again after striking double gold on the track.