The Italian’s strong start at the Royal Artillery Barracks was enough to guarantee him top honours on his swansong appearance, following up a perfect opening set by dropping just four points in the second.
Sanawi edged the next two sets but the match was beyond the Malaysian in the shoot-off and he took silver following a 6-5 defeat.
De Pellegrin needed a 10 from his final arrow to win a dramatic semi-final against Tseng Lung Hui, who later claimed bronze with a 7-3 victory over experienced Iranian Ebrahim Ranjbarkivaj.
The retiring Italian archer said: 'It has been a fantastic Paralympics for me.
'It has not been easy for me to come here and say it was my last Paralympics and to keep concentrated enough to win the gold. It's fantastic to end my career like this.
'I want to thank everyone who has helped me throughout my career, including my friends and family, and my coach.'
Russia took all three medals on offer in the men’s Individual Recurve - Standing as Timur Tuchinov claimed gold with a 7-3 triumph over Oleg Shestakov.
Eric Bennett of the USA was given little chance by the remaining Russian, Mikhail Oyun, who won bronze with a comprehensive 6-0 victory.
'I was actually calm,' said Tuchinov. 'It's my team-mate, it's not the first time that we have competed against each other.
'We have competed in various championships. Playing with a team-mate in the final is actually more calming.'
The USA did get among the Archery golds, though, as Jeff Fabry saw off the threat of the Czech Republic’s David Drahoninsky with a 6-2 success in the men's Individual Compound - W1.
The right-hander, who broke his primary bow during the semi-finals, shot a final 10 to rubber stamp his triumph.
A relieved Fabry said: 'I was fortunate that I went and got my back-up bow, which I should have had on me in the first place. It's never happened to me before.'
Norbert Murphy won bronze by cruising to a comfortable 7-1 win over Osmo Kinnunen of Finland.
Eighteen-year-old Jere Forsberg and Matt Stutzman played out a dramatic men’s Individual Compound - Open final.
The USA athlete needed his opponent to drop three points with his final arrow of a tense shoot-off but Forsberg held his nerve to claim gold.
Turkey’s Dogan Hanci had earlier beaten Guillermo Rodriguez Gonzalez of Spain to take bronze.