There was an illustrious name in her box in the form of US First Lady Michelle Obama as Williams played Jelena Jankovic.
She had a potentially tricky draw against the Serbian former world number one but went into the match on a run of 11 straight victories and won 6-3 6-1.
Williams, who next meets Poland's Urszula Radwanska, was inspired by her famous guest and gave the First Lady a thumbs-up at the end of her match.
'They asked me did I mind if she sat in the family box,' said Williams. 'I was like, "Of course not. Please, it would be my honour". I love Michelle, so it was good.
'I gave her a thumbs-up just to acknowledge that I knew she was here. Obviously it was impossible not to see her but it was cool.'