The USA recorded their 39th straight Olympic win in emphatic style against their North American neighbours.
Geno Auriemma's team put aside the first-quarter struggles they have been experiencing so far in these Games to dominate from start to finish, leading 19-8 at the end of the first period and 42-21 by half-time.
The USA dominated in every category, shooting 47 per cent from the field to Canada's 30 per cent, and out-rebounding them 48-31.
Diana Taurasi scored 15 points for the USA, while Candace Parker and Sylvia Fowles had 12 each, Parker adding seven rebounds.
Parker appeared to hurt her ankle, but said after the game: 'My ankle is good, I tweaked it a little bit but it's okay. Nothing that will keep me out.'
Maya Moore and Angel McCoughtry also reached double figures with 11 points.
But it was the team's defence that sparked the dominating performance as Canada struggled to make shots or get offensive rebounds.
In their six games so far at London 2012, the USA have won by an average of 42.6 per game.