The Swiss star, who has been named as the top seed in the men's Singles tournament, will be hoping to continue his run of success on the courts of the All England Club when the action begins on Saturday.
On paper, he will be the favourite to progress, but Federer will be wary of the world number 51, who he nearly lost to in the first round of Wimbledon in 2010.
Also in Federer's half of the draw are 10th seed John Isner of the USA, eighth-seeded Argentinian Juan Martin Del Potro and fourth seed David Ferrer, the leading Spaniard in the absence of the injured Rafael Nadal, the gold medallist from Beijing 2008.
Great Britain's Andy Murray has been handed an extremely tough first-round match against Switzerland's Stanislas Wawrinka - the world number 26, who he has lost to four times in 10 meetings, including in the third round of the US Open two years ago.
The pair also had a very close battle under the roof at Wimbledon in the fourth round in 2009, with Murray eventually winning in five sets.
Novak Djokovic will face Italy's Fabio Fognini in the first round and could ultimately meet French fifth seed Jo-Wilfried Tsonga in a potential quarter-final clash.
In the women's Singles, top seed Victoria Azarenka of Belarus will face Romania's Irina-Camelia Begu in round one, while second seed and Wimbledon runner-up Agnieszka Radwanska of Poland meets big-hitting German Julia Goerges.
Wimbledon champion Serena Williams is seeded fourth and faces former world number one Jelena Jankovic from Serbia in a standout first-round clash, with sister Venus taking on ninth seed Sara Errani from Italy.
Both Williams sisters are in Azarenka's half of the draw, while in the bottom half, third seed Maria Sharapova faces Israel's Shahar Peer in round one.
In the men's Doubles, Andy and Jamie Murray will play Austrian pair Jurgen Melzer and Alexander Peya, while defending champions Wawrinka and Federer take on Japan's Kei Nishikori and Go Soeda.
Top seeds Bob and Mike Bryan of the USA face Thomaz Bellucci and Andre Sa of Brazil.
In the women's Doubles, top seeds Liezel Huber and Lisa Raymond of the USA were given a bye while defending champions the Williams sisters are unseeded and will take on Sorana Cirstea and Simona Halep of Romania in round one.